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Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice. |
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| Authors: | K Nakanaga K Yamanouchi K Fujiwara |
| Abstract: | Neutralizing and nonneutralizing monoclonal antibodies to the peplomer glycoprotein and nucleocapsid protein of a mouse hepatitis virus (MHV), MHV-NuU, protected mice against lethal MHV-2 challenge. Histopathologically, livers of mice receiving protective antibodies showed some focal necrotic lesions with remarkable cellular infiltration instead of fulminant hepatitis caused by MHV-2. |
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