Telomerase inhibiting activity in vitro from natural resources, marine algae extracts |
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| Authors: | Kazunori Kanegawa Hideki Harada Hisashi Myouga Yoshinori Katakura Sanetaka Shirahata Yuto Kamei |
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| Institution: | (1) Marine and Highland Bioscience Center, Saga University, 152-1 Shonan-cho, Karatsu, Saga, 847-0021, Japan;(2) Graduate School of Genetic Resources Technology, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka, 812, Japan;(3) Marine and Highland Bioscience Center, Saga University, 152-1 Shonan-cho, Karatsu, Saga, 847-0021, Japan |
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| Abstract: | We attempted to screen for telomerase inhibitingactivity in vitro from a total of 304 marine algae samples which were collected from various Japancoasts by nonradioisotope telomeric repeatamplification protocol (Non-RI TRAP) assay using humanleukemia MOLT-4 cells. Ten of the MeOH extracts andtwo of the PBS extracts from those algal samplesshowed telomerase inhibiting activity. In particular,the MeOH extract from a green alga, Caulerpasertularioides strongly inhibited telomerase activitywhen added to MOLT-4 cell culture at a level of 1.25%(v/v), suggesting that it may be possible to developa novel anti-cancer agent in view of its specificanti-telomeric property. |
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| Keywords: | marine algae extract telomerase inhibiting activity telomere TRAP |
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