Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats |
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Authors: | Shahrzad Jalali Yuexi Huang Daniel J Dumont Kullervo Hynynen |
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Affiliation: | 1.Molecular and Cellular Biology Research, Sunnybrook Research Institute,Sunnybrook Health Sciences Centre,Toronto,Canada;2.Department of Medical Biophysics,University of Toronto and Discipline of Imaging Research, Sunnybrook Health Sciences Centre,Toronto,Canada |
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Abstract: | Background The Blood Brain Barrier (BBB) maintains the homeostasis of central nervous system by preventing the free passage of macromolecules from the systemic circulation into the brain. This normal physiological function of the BBB presents a challenge for delivery of therapeutic compounds into the brain. Recent studies have shown that the application of focused ultrasound together with ultrasound contrast agent (microbubbles) temporarily increases the permeability of the BBB. This effect is associated with breakdown of tight junctions, the structures that regulate the paracellular permeability of the endothelial cell layer. The influence of this ultrasound effect on the activation of intracellular signaling proteins is currently not well understood. Therefore, the aim of this study was to investigate the activation of cell survival signaling molecules in response to ultrasound-mediated BBB opening; |
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