Molecular oncology focus - Is carcinogenesis a 'mitochondriopathy'? |
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| Authors: | Anna M Czarnecka Jerzy S Czarnecki Wojciech Kukwa Francesco Cappello Anna Ścińska Andrzej Kukwa |
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| Institution: | (1) Laboratory of Molecular Oncology, Department of Oncology, Military Institute of the Health Services, Warsaw, Poland;(2) Department of Knowledge Management, Faculty of Management, University of Lodz, Lodz, Poland;(3) Department of Otolaryngology, Czerniakowski Hospital, Medical University of Warsaw, Warsaw, Poland;(4) Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Palermo, Italy |
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| Abstract: | Mitochondria are sub-cellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS).
As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular techniques, alterations in respiratory
activity and in mitochondrial DNA (mtDNA) appear to be common features of malignant cells. Somatic mtDNA mutations have been
reported in many types of cancer cells, and some reports document the prevalence of inherited mitochondrial DNA polymorphisms
in cancer patients. Nevertheless, a careful reanalysis of methodological criteria and methodology applied in those reports
has shown that numerous papers can't be used as relevant sources of data for systematic review, meta-analysis, or finally
for establishment of clinically applicable markers. |
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