Genetic polymorphism of complement factor H in cattle |
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| Authors: | H Tabel H J Groat G J Kraay W P Aston |
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| Affiliation: | Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada. |
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| Abstract: | Bovine factor H was found to be polymorphic by the combined techniques of SDS-polyacrylamide electrophoresis of bovine plasma and immunoblotting. Three phenotypes (S, SF, F) were identified in a sample population of 149 cattle. Variant S and F differed by an apparent molecular weight of 5000 daltons. Family studies demonstrated Mendelian segregation of variants S and F. The data indicate that these genetic variants of bovine factor H are encoded by two codominant alleles at a single autosomal locus. |
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| Keywords: | cattle alternative complement pathway factor H genetics |
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