Enantiotopic Selectivity of-Pig Liver Esterase Isoenzymes |
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| Authors: | Niklas
hrner Anders Mattson Torbj rn Norin Karl Hult |
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| Institution: |
a Department of Biochemistry and Biotechnology, Royal Institute of Technology, Stockholm, Sweden
b Department of Organic Chemistry, Royal Institute of Technology, Stockholm, Sweden |
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| Abstract: | Pig liver esterase was separated into isoenzyme fractions with known subunit compositions. The fractions showed differences in enantiotopic ester group selectivity in hydrolysis of two substrates of synthetic value, benzylmethylpropanedioic acid dimethyl ester and cis-N-benzyl-2,5-bismethoxy-carbonylpyrrolidine. A difference in aliphatic chain length specificity between the isoenzyme fractions was also observed. The results indicate that pig liver esterase cannot be regarded as homogeneous when used in organic synthesis. |
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| Keywords: | Pig liver esterase isoenzymes enantiotopic selectivity bioorganic synthesis |
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