Synthesis of fluorescent molecular probes specific for the receptor of blepharismone, a mating-inducing pheromone of the ciliate Blepharisma japonicum |
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Authors: | Uruma Yoshiyuki Sugiura Mayumi Harumoto Terue Usuki Yoshinosuke Iio Hideo |
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Affiliation: | Department of Material Science, Graduate School of Science, Osaka City University, Osaka 558-8585, Japan. |
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Abstract: | Blepharismone (gamone 2) is a mating-inducing pheromone of the ciliate Blepharisma japonicum. N-Pyrenylbutyryl-blepharismone and N-biphenylacetyl-blepharismone, which are fluorescent derivatives of blepharismone, were synthesized as molecular probes for the gamone 2 receptor. Further, we proved that they have inhibitory activities against the blepharismone-induced monotypic pairing of B. japonicum. |
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