Enzymatic fucosylations with purine-diphosphate-fucoses (PDP-Fucoses) |
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| Authors: | Gabi Baisch Reinhold Öhrlein Andreas Katopodis |
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| Institution: | Central Research Laboratories CIBA AG, Schwarzwaldallee 211, CH-, Basle, Switzerland |
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| Abstract: | Two cloned fucosyltransferases, Fuc-t III and Fuc-t VI, are probed on a preparative scale with non-natural donor-substrates, in which the guanosine of the natural donor guanosine-diphosphate-fucose is replaced by other purines. Surprisingly, the novel purine-diphosphate-fucoses (PDP-Fuc) are recognized by both enzymes as donor-substrates. |
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