Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy |
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Authors: | Araújo-Jorge Tania C Waghabi Mariana C Soeiro Maria de Nazaré C Keramidas Michelle Bailly Sabine Feige Jean-Jacques |
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Affiliation: | Tania C. , Mariana C. , Maria de Nazaré C. , Michelle , Sabine ,Jean-Jacques , |
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Abstract: | This paper summarizes recent data from the literature suggesting that transforming growth factor-β (TGF-β) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-β in Chagas disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-β-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T. cruzi infection. |
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Keywords: | TGF-β Chagas disease Trypanosoma cruzi Cardiac fibrosis |
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