Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease |
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| Authors: | Torres Vicente E Wang Xiaofang Qian Qi Somlo Stefan Harris Peter C Gattone Vincent H |
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| Institution: | Division of Nephrology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. torres.vicente@mayo.edu |
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| Abstract: | Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. The vasopressin V2 receptor (VPV2R) antagonist OPC31260 has been effective in two animal models of PKD with pathologies that are probably related. Here we show, in a mouse model of ADPKD (Pkd2(-/tm1Som)), a similar cellular phenotype and response to OPC31260 treatment, with reduction of renal cyclic AMP (cAMP) levels, prevention of renal enlargement, marked inhibition of cystogenesis and protection of renal function. |
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