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Itaconic acid production by immobilizedAspergillus terreus on sucrose medium
Authors:H. Kautola  N. Vassilev  Y. -Y. Linko
Affiliation:(1) Laboratory of Biotechnology and Food Engineering, Helsinki University of Technology, SF-02150 Espoo, Finland;(2) Present address: Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Abstract:Summary The itaconic acid production by immobilizedAspergillus terreus TTK 200-5-3 mycelium was optimized in shake flask fermentations using statistical experimental design and empirical modelling. The maximum itaconic acid concentration was calculated to be 13.3 g/l in the investigated experimental area when initial sucrose concentration was 10%, ammonium nitrate concentration 0.275% and initial pH 3. The itaconic acid product concentration using immobilized mycelium was about double of that obtained with the free mycelium.
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