A complete backbone spectral assignment of lipid-free human apolipoprotein E (apoE) |
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Authors: | Yonghong Zhang Jianglei Chen Jianjun Wang |
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Institution: | (1) Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA |
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Abstract: | Apolipoprotein E is an exchangeable apolipoprotein that plays an important role in lipid/lipoprotein metabolism and cardiovascular
diseases. Recent evidence indicates that apoE is also critical in several other important biological processes, including
Alzheimer’s disease, cognitive function, immunoregulation, cell signaling and infectious diseases. Although the X-ray crystal
structure of the apoE N-terminal domain was solved in 1991, there is no structure available for the apoE C-terminal domain
and full-length apoE. Here we report a complete NMR backbone spectral assignment of lipid-free human apoE. |
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Keywords: | Apolipoprotein E Atherosclerosis LDL receptor Heart disease Alzheimer’ s disease |
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