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Gene expression in the polycistronic operons of Escherichia coli heat-labile toxin and cholera toxin: a new model of translational control |
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| Authors: | T Yamamoto A Suyama N Mori T Yokota A Wada |
| Affiliation: | 1. Department of Bacteriology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan;2. Department of Physics, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan;3. Department of Biochemistry, School of Pharmaceutical Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan |
| Abstract: | A new model is proposed based on the suggestion that stable local secondary structures of mRNA interfere with ribosome movement on mRNA and consequently reduce the translation rate. This model accounts for a different level of translation for each cistron in the polycistronic mRNA of Escherichia coli heat-labile toxin (LT) and cholera toxin. We also conclude that the mRNA secondary structures have been conserved during the evolution of the toxin genes for its functional importance. |
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