New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase |
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| Authors: | Fonvielle Matthieu Therisod Helene Hemery Marion Therisod Michel |
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| Institution: | Equipe Chimie Bioorganique et Bioinorganique, ICMMO, Univ Paris-Sud, UMR 8182, F-91405 Orsay, France. |
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| Abstract: | We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 microM, might be of interest as an anti-obesity drug. |
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