Alzheimer's disease: coated vesicles, coated pits and the amyloid-related cell |
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| Authors: | A Roher E G Gray M Paula-Barbosa |
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| Affiliation: | Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201. |
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| Abstract: | The amyloid-related cell (ARC) of the neuritic plaques of Alzheimer's disease revealed numerous cytoplasmic projections surrounding extracellular amyloid material. It is proposed that ARC-coated vesicles fuse with the cell membrane, forming coated pits, which may empty their secretory material into the extracellular space where polymerization of amyloid filaments could occur. |
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