Effect of dissolved oxygen concentration and impeller tip speed on itaconic acid production by Aspergillus terreus |
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Authors: | Yong Soo Park Noriyasu Ohta Mitsuyasu Okabe |
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Institution: | (1) Biochemical Engineering Lab., Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, 422 Shizuoka, Japan |
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Abstract: | Summary Effect of aeration rate and impeller tip speed on mycelium growth and itaconic acid production was investigated in a batch culture of Aspergillus terreus IFO-6365. When impeller tip speed was 94.2 cm/sec at a fixed aeration rate of 0.5 vvm, itaconic acid concentration was 3.6 and 1.6 times higher than those in the impeller tip speed of 62.8 and 125.7 cm/sec, respectively. When an oxygen-enriched air was supplied at a fixed impeller tip speed of 94.2 cm/sec and dissolved oxygen concentration was maintained in the 20–60 % range, both itaconic acid concentration and mycelium growth were not affected by the dissolved oxygen concentration. |
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