Sex-linked,androgen-dependent differences in renal retention of trimethylselenonium ions |
| |
Authors: | Jiří Pařízek Jana Kalousková Ladislav Pavlík Miroslav Stýblo |
| |
Affiliation: | (1) Institute of Physiology, Czechoslovak Academy of Sciences, Vídeňská 1083, 142 20 Prague 4, Czechoslovakia;(2) Institute of Nuclear Biology and Radiochemistry, Czechoslovak Academy of Sciences, Vídeňská 1083, 142 20 Prague 4, Czechoslovakia |
| |
Abstract: | The metabolism of trimethylselenonium ions (TMSe) was studied in male and female rats during maturation. Selenium (Se) retention in the whole body as well as in organs was found to be significantly higher in male rats than in female a few hours after parenteral administration of TMSe. The pronounced Se accumulation was observed in male kidneys. This sex-linked difference was dependent on the presence of gonades and started to be manifested with sexual maturation during the third decade of postnatal life. The effects of steroid hormones on the retention of Se from TMSe were examined in female and castrated male rats. The results indicate that TMSe metabolism in rat kidneys may be influenced by androgen steroids. |
| |
Keywords: | Trimethylselenonium ions selenium whole body retention renal retention sex-linked androgen-dependent kidneys |
本文献已被 SpringerLink 等数据库收录! |