Phosphoprotein-phosphatase activity associated with human placental alkaline phosphatase. |
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| Authors: | K P Huang J C Robinson J Y Chou |
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| Affiliation: | Section on Developmental Enzymology, Laboratory of Biomedical Sciences National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland 20014 USA |
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| Abstract: | Human placental alkaline phosphatase, a marker protein for some nontrophoblastic neoplasms, was found to have phosphoprotein phosphatase activity. This was demonstrated by the dephosphorylation of 32P-labeled histones, protamine, glycogen synthetase, casein, and phosvitin at various pH values. Unlike the general phosphoprotein phosphatase, the placental alkaline phosphatase does not have phosphorylase phosphatase activity. |
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