The unfolded protein response |
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Authors: | Martin Schröder |
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Institution: | (1) School of Biological and Biomedical Sciences, University of Durham, DH1 3LE Durham, UK |
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Abstract: | The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic
reticulum (ER). The UPR coordinates adaptive responses to this stress situation, including induction of ER resident molecular
chaperone and protein foldase expression to increase the protein folding capacity of the ER, induction of phospholipid synthesis,
attenuation of general translation, and upregulation of ER-associated degradation to decrease the unfolded protein load of
the ER, and an antioxidant response. Upon severe or prolonged ER stress the UPR induces apoptosis to eliminate unhealthy cells
from an organism or a population. In this review, I will summarize our current knowledge about signal transduction pathways
involved in transducing the unfolded protein signal from the ER to the nucleus or the cytosol. |
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Keywords: | Endoplasmic reticulum molecular chaperone recombinant protein production signal transduction unfolded protein response |
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