Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. |
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| Authors: | K Takahashi S Sonoda K Higashi T Kondo H Takahashi M Takahashi and K Yamanishi |
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| Institution: | Department of Virology, Research Institute for Microbial Diseases, Osaka University, Japan. |
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| Abstract: | Human herpesvirus 6 (HHV-6)-related virus was isolated from CD4+ CD8- and CD3+ CD4+ mature T lymphocytes but could not be isolated from CD4- CD8+, CD4- CD8-, and CD3- T cells in the peripheral blood of exanthem subitum patients. HHV-6-related virus predominantly infected CD4+ CD8+, CD4+ CD8-, and CD3+ CD4+ cells with mature phenotypes and rarely infected CD4- CD8+ cells from cord blood mononuclear cells, which suggested predominant CD4 mature T-lymphocyte tropism of HHV-6-related virus. |
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