Antimicrobial activity of some substituted triazoloquinazolines |
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Authors: | S Jantová R Ovádeková S Leta?iová K ?pirková ? Stankovský |
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Institution: | Department of Biochemistry and Microbiology, Slovak University of Technology, 812 37 Bratislava, Slovakia. |
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Abstract: | Fifteen substituted 1,2,4-triazolo4,3-c]quinazolines were tested for antibacterial and antifungal effects. The most effective derivatives had the triazoloquinazoline skeleton substituted with the pharmacologically active chromophores--morpholine, chlorine and nitro group. The broadest antimicrobial activity was found with 5-morpholin-4-yl-3-(5-nitrothien-2-yl)1,2,4]triazolo4,3-c]quinazoline in concentration of 10 mg/L for B. subtilis, 50 mg/L for S. aureus and 100 mg/L for C. tropicalis. The highest tested concentration of derivative caused 83% growth inhibition of R. nigricans. |
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