Prediction of B cell and T cell epitopes of DBLalpha domain in Plasmodium falciparum malaria vaccine candidate var gene |
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| Authors: | Ozarkar Aarti D Prakash D Deobagkar Dileep N Deobagkar Deepti D |
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| Affiliation: | Molecular Biology Research Laboratory, Department of Zoology and Institute of Bioinformatics and Biotechnology, University of Pune, Pune-411007, India. |
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| Abstract: | P. falciparum encodes PfEMP-1 which is important in pathogenicity and virulence. We have analyzed the structure of the Duffy binding like (DBLalpha) domain of var genes and predicted the antigenic sites and T and B cell epitopes which present a highly variable picture with major implications in immune interactions and vaccine design. |
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