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New approaches to predict the effect of co-occurring variants on protein characteristics |
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| Authors: | David Holcomb Nobuko Hamasaki-Katagiri Kyle Laurie Upendra Katneni Jacob Kames Aikaterini Alexaki Haim Bar Chava Kimchi-Sarfaty |
| Affiliation: | 1. Division of Plasma Protein Therapeutics, Office of Tissue and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA;2. Department of Statistics, University of Connecticut, Storrs, CT 06268, USA |
| Abstract: | |
| Keywords: | single nucleotide variant SNV effect of co-occurring genetic variants pathogenicity and protein effectiveness prediction tool datasets of monogenic diseases synonymous variants cooperative and antagonistic effects |
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