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High prevalence of multilocus pathogenic variation in neurodevelopmental disorders in the Turkish population
Affiliation:1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA;2. Department of Pediatric Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep 27310, Turkey;3. Department of Medical Genetics, Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey;4. Department of Medical Genetics, Kanuni Sultan Suleyman Training and Research Hospital, 34303 Istanbul, Turkey;5. Section of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA;6. Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA;7. Department of Medical Genetics, Adana City Training and Research Hospital, Adana 01170, Turkey;8. Departments of Medical Genetics, School of Medicine, Istanbul Medipol University, Istanbul 34810, Turkey;9. University of Health Sciences Zubeyde Hanim Research and Training Hospital of Women’s Health and Diseases, Department of Medical Genetics, Ankara 06080, Turkey;10. Istanbul Faculty of Medicine, Department of Medical Genetics, Istanbul University, Istanbul 34093, Turkey;11. Centre of Genetics Diagnosis, Zeynep Kamil Maternity and Children’s Training and Research Hospital, Istanbul, Turkey;12. Private Reyap Istanbul Hospital, Istanbul 34515, Turkey;13. Department of Medical Genetics, School of Medicine, Marmara University, Istanbul 34722, Turkey;14. Department of Pediatric Genetics, School of Medicine, Marmara University, Istanbul 34722, Turkey;15. Eastern Mediterranean University Medical School, Magosa, Mersin 10, Turkey;16. Medical Genetics Section, Balikesir Ataturk Public Hospital, Balikesir 10100, Turkey;17. Department of Medical Genetics, Samsun Education and Research Hospital, Samsun 55100, Turkey;18. Department of Medical Genetics, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara 06110, Turkey;19. Department of Medical Genetics, Gulhane Military Medical School, Ankara 06010, Turkey;20. Department of Medical Genetics, School of Medicine, University of Inonu, Malatya 44280, Turkey;21. Department of Medical Genetics, Afyon Kocatepe University, School of Medicine, Afyon 03218, Turkey;22. Division of Critical Care Medicine, Department of Pediatrics, School of Medicine, Bezmialem Foundation University, Istanbul 34093, Turkey;23. Department of Pediatrics, Division of Pediatric Critical Care Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey;24. Department of Pediatrics and Pediatric Neurology, Faculty of Medicine, Inonu University, Malatya 34218, Turkey;25. Department of Medical Genetics, University of Health Sciences, Ankara Training and Research Hospital, Ankara 06110, Turkey;26. Department of Medical Genetics, Cukurova University Faculty of Medicine, Adana 01330, Turkey;27. Department of Medical Genetics, Konya Training and Research Hospital, Konya 42250, Turkey;28. Department of Medical Genetics, School of Medicine, Trakya University, Edirne 22130, Turkey;29. Department of Medical Genetics, Ankara City Hospital, Ankara 06800, Turkey;30. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030, USA;31. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA;32. Texas Children’s Hospital, Houston, TX 77030, USA;33. Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX 77030, USA
Abstract:
Keywords:neurodevelopmental disorders  multilocus pathogenic variation  exome reanalysis  whole-genome sequencing  identity-by-descent (IBD)  runs of homozygosity (ROH)
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