Pathogenic antibodies to AQP4: Neuromyelitis optica spectrum disorder (NMOSD) |
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| Affiliation: | 1. Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, UK;2. Dept. of Paediatric Neurology, The Birmingham Women''s and Children''s Hospital NHS Foundation Trust, Birmingham, UK;3. Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK |
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| Abstract: | NMOSD is a rare but severe relapsing remitting demyelinating disease that affects both adults and children. Most patients have pathogenic antibodies that target the central nervous system AQP4 protein. This review provides an update on our current understanding of the disease pathophysiology and describes the clinical, paraclinical features and therapeutic management of the disease. |
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