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A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor,AHR
Authors:Mai Xu  Lindsey Mehl  Tongwu Zhang  Rohit Thakur  Hayley Sowards  Timothy Myers  Lea Jessop  Alessandra Chesi  Matthew E Johnson  Andrew D Wells  Helen T Michael  Patricia Bunda  Kristine Jones  Herbert Higson  Rebecca C Hennessey  Ashley Jermusyk  Michael A Kovacs  Maria Teresa Landi  Mark M Iles  Alisa M Goldstein  Melanoma Meta-Analysis Consortium  Jiyeon Choi  Stephen J Chanock  Struan FA Grant  Raj Chari  Glenn Merlino  Matthew H Law  Kevin M Brown
Institution:1. Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA;2. Integrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA;3. Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA;4. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;5. Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;6. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA;7. Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA;8. Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds LS2 9NL, UK;9. Leeds Institute for Data Analytics, University of Leeds, Leeds LS2 9NL, UK;10. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA;11. Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;12. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;13. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;14. Genome Modification Core, Frederick National Lab for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA;15. Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia;16. School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4059, Australia
Abstract:
Keywords:melanoma  tanning  ultraviolet radiation  UVR  genome-wide association study  GWAS  expression quantitative trait locus  eQTL  fine-mapping  aryl hydrocarbon receptor  AHR  melanocyte
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