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Comparative single-cell analysis of biopsies clarifies pathogenic mechanisms in Klinefelter syndrome
Authors:Eisa Mahyari  Jingtao Guo  Ana C Lima  Daniel P Lewinsohn  Alexandra M Stendahl  Katinka A Vigh-Conrad  Xichen Nie  Liina Nagirnaja  Nicole B Rockweiler  Douglas T Carrell  James M Hotaling  Kenneth I Aston  Donald F Conrad
Institution:1. Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Portland, OR 97006, USA;2. Andrology and IVF Laboratory, Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84108, USA;3. Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT 84112, USA;4. Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA;5. Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA;6. Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT 63110, USA
Abstract:
Keywords:Klinefelter syndrome  male infertility  testis  single-cell sequencing  azoospermia  Leydig cells  Sertoli cells  X chromosome inactivation  matrix factorization  SDA
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