Early-phase migration dynamics of Echinococcus multilocularis in two mouse strains showing different infection susceptibilities |
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| Affiliation: | 1. Laboratory of Parasitology, Department of Disease Control, Graduate School of Infectious Diseases, Faculty of Veterinary Medicine, Hokkaido University, N 18 W 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan;2. Department of Infectious Diseases, Hokkaido Institute of Public Health, N 19 W 12, Sapporo, Hokkaido 060-0819, Japan;3. Laboratory of Veterinary Parasitic Diseases, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai-Nishi, Miyazaki 889-2192, Japan |
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| Abstract: | The early-phase migration dynamics of Echinococcus multilocularis in the intermediate hosts remain largely unknown. We compared the parasite burden in the intestine, liver and faeces of DBA/2 and C57BL/6 mouse strains using parasite-specific quantitative PCR. Our results indicated that the parasites invaded mainly from the middle segments of the small intestine and completed migration to the liver within 24 h p.i. C57BL/6 mice had lower parasite DNA burdens in the intestine and liver but higher in the faeces than DBA/2 mice, suggesting that parasite invasion of the intestine may be a critical stage regulating susceptibility to E. multilocularis infection in mice. |
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| Keywords: | Migration dynamics Oncospheres Primary alveolar echinococcosis qPCR |
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