A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses |
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| Authors: | Frederick A. Matsen IV Christopher T. Small Khanh Soliven Gregory A. Engel Mostafa M. Feeroz Xiaoxing Wang Karen L. Craig M. Kamrul Hasan Michael Emerman Maxine L. Linial Lisa Jones-Engel |
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| Affiliation: | 1.Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America;2.University of Washington, Seattle, Washington, United States of America;3.Swedish Medical Center, Seattle, Washington, United States of America;4.Jahangirnagar University, Savar, Dhaka, Bangladesh;University of California San Diego, United States of America |
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| Abstract: | Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo. |
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