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n-3 Fatty Acid Deficiency Increases Brain Protein Synthesis in the Free-Moving Adult Rat

Authors:	Murielle Giaume Nadine Gay Valérie Baubet †Abdallah Gharib ‡Georges Durand Pierre Bobillier † Nicole Sarda

Institution:	CERMEP, Hôpital Neurologique;; CNRS URA 1195, Laboratoire d'Anatomie Pathologique, UFR A. Carrel, Lyon;; INSERM U. 352, Laboratoire de Chimie Biologique, INSAL, Villeurbanne;and; INRA, Laboratoire de Nutrition et SécuritéAlimentaire, Jouy en Josas, France

Abstract:	Abstract: The autoradiographic method with l -³⁵S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control animals. Biochemical analysis confirmed the increase in overall rate of protein synthesis in brain as a whole.

Keywords:	Brain protein synthesis l-[³⁵S]Methionine Quantitative autoradiography n-3 fatty acid deficiency Adult rat