Functional aspects of PARylation in induced and programmed DNA repair processes: Preserving genome integrity and modulating physiological events |
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Authors: | Isabelle Robert,Olga Karicheva,Bernardo Reina San Martin,Valé rie Schreiber,Franç oise Dantzer |
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Affiliation: | 1. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de Santé et de Recherche Médicale (INSERM), Centre National de Recherche Scientifique (CNRS), UMR 7104, Université de Strasbourg, 67404 Illkirch, France;2. UMR 7242-CNRS Université de Strasbourg, Laboratoire of Excellence Medalis, Institut de Recherche de l’Ecole de Biotechnologie de Strasbourg, Ecole Supérieure de Biotechnologie de Strasbourg, Bld. S. Brant, BP10413, 67412 Illkirch, France |
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Abstract: | To cope with the devastating insults constantly inflicted to their genome by intrinsic and extrinsic DNA damaging sources, cells have evolved a sophisticated network of interconnected DNA caretaking mechanisms that will detect, signal and repair the lesions. Among the underlying molecular mechanisms that regulate these events, PARylation catalyzed by Poly(ADP-ribose) polymerases (PARPs), appears as one of the earliest post-translational modification at the site of the lesion that is known to elicit recruitment and regulation of many DNA damage response proteins. |
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Keywords: | Poly(ADP-ribose) polymerases DNA repair Stress-induced DNA damage Developmentally programmed DNA damage Genome integrity B cell receptor assembly and diversification |
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