Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer |
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| Authors: | Natalie Jä ger,Matthias Schlesner,David T.W. Jones,Simon Raffel,Jan-Philipp Mallm,Kristin M. Junge,Dieter Weichenhan,Tobias Bauer,Naveed Ishaque,Marcel Kool,Paul A. Northcott,Andrey Korshunov,Ruben M. Drews,Jan Koster,Rogier Versteeg,Julia Richter,Michael Hummel,Stephen C. Mack,Michael D. Taylor,Hendrik Witt,Benedict Swartman,Dietrich Schulte-Bockholt,Marc Sultan,Marie-Laure Yaspo,Hans Lehrach,Barbara Hutter,Benedikt Brors,Stephan Wolf,Christoph Plass,Reiner Siebert,Andreas Trumpp,Karsten Rippe,Irina Lehmann,Peter Lichter,Stefan M. Pfister,Roland Eils |
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| Affiliation: | 1 Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;2 Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;3 Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;4 Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGBMH), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;5 Research Group Genome Organization and Function, DKFZ and BioQuant, 69120 Heidelberg, Germany;6 UFZ, Helmholtz Centre for Environmental Research Leipzig, Department of Environmental Immunology, 04318 Leipzig, Germany;7 Division of Epigenomics and Cancer Risk Factors, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;8 Department of Neuropathology, University of Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany;9 Clinical Cooperation Unit Neuropathology, DKFZ, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany;10 Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands;11 Institute of Human Genetics, Christian-Albrechts-University, Schwanenweg 24, 24105 Kiel, Germany;12 Institute of Pathology, Charité-University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany;13 Division of Neurosurgery and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada;14 Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany;15 Department of Trauma and Orthopaedic Surgery, BG Trauma Centre, 67071 Ludwigshafen, Germany;16 Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany;17 Genomics and Proteomics Core Facility, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;18 German Cancer Consortium (DKTK), 69120 Heidelberg, Germany;19 Division of Molecular Genetics, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;20 Institute of Pharmacy and Molecular Biotechnology, Bioquant Center, University of Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany;21 Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany |
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