Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors |
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| Authors: | Brooke M. Emerling,Jonathan B. Hurov,George Poulogiannis,Kazumi S. Tsukazawa,Rayman Choo-Wing,Gerburg M. Wulf,Eric L. Bell,Hye-Seok Shim,Katja A. Lamia,Lucia E. Rameh,Gary Bellinger,Atsuo T. Sasaki,John M. Asara,Xin Yuan,Andrea Bullock,Gina M. DeNicola,Jiaxi Song,Victoria Brown,Sabina Signoretti,Lewis C. Cantley |
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| Affiliation: | 1 Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA;2 Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA;3 Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA;4 Agios Pharmaceuticals, Cambridge, MA 02139, USA;5 Department of Biology, Paul F. Glenn Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;6 Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA;7 Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA;8 Department of Internal Medicine, University of Cincinnati College of Medicine, UC Neuroscience Institute, Brain Tumor Center, Cincinnati, OH 45267, USA;9 Department of Medicine, Harvard Medical School, Boston, MA 02115, USA;10 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA;11 Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA |
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