A large conductance,voltage- and calcium-activated K+ channel in the basolateral membrane of rat enterocytes |
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Institution: | 1. MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, PO Box 147, Liverpool L69 3BX England;2. Zoology Department, University of Liverpool, Liverpool L69 3BX, England |
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Abstract: | The patch-clamp technique was employed to record single channel currents in patches of basolateral membrane from enterocytes isolated from rat small intestine. We demonstrate the presence of a large conductance (250 pS), voltage- and calcium-activated, the maxi. K+ channel in this membrane. Currents in this K+ channel were blocked by the application of barium (5 mM) to the extracellular membrane face. |
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