Synthesis and binding affinity of a chiral PNA analogue |
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Authors: | Li Y Jin T Liu K |
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Institution: | Beijing Institute of Pharmacology & Toxicology, China. |
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Abstract: | The synthesis of a chiral peptide nucleic acid (PNA), which is composed of N-aminoethyl-cis-4-nucleobase-L-proline units, was described. The chiral PNA monomers containing all four nucleobases (A. T, C and G) were steroselectively prepared. The x-ray diffraction data from a single crystal confirmed the configuration of a key intermediate. Binding activity of the oligomers with their complementary DNA targets was also investigated. |
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