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Presence of immunoassayable beta-lipotropin in bovine brain and spinal cord: lack of concordance with ACTH concentrations.
Authors:D T Krieger  A Liotta  T Suda  M Palkovits  M J Brownstein
Affiliation:1. Department of Medicine, Mount Sinai School of Medicine, New York, N.Y. 10029, USA;2. First Department of Anatomy, Semmelweis Medical University, Budapest, Hungary;3. Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014 USA
Abstract:Discrete areas of freshly obtained adult bovine brain were assayed for their content of immunoreactive β-lipotropin (β-LPH), ACTH and β-endorphin. Highest concentrations (pg/100ug protein) of β-LPH were present in hypothalamus (517 ± 81), hippocampus (218 ± 60), central grey rostral mesencephalic level, pons, striatum, and spinal cord (163–258). Lesser concentrations (49–138) were present in other parts of the limbic system, brain stem, cortex and thalamus. Immunoreactive ACTH concentrations were highest in hypothalamus (1702 ± 487) and hippocampus (210 ± 40), with markedly lesser concentrations (5–24) being present in all the other aforementioned areas. Immunoreactive β-endorphin concentrations in hypothalamus were 1990 ± 510, in hippocampus 280 ± 50.
Keywords:β-lipotropin  ACTH  Adrenocorticotropic hormone  human ACTH  MSH  Melanocyte stimulating hormone  CNS  Central nervous system
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