PDP: protein domain parser |
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Authors: | Alexandrov Nickolai Shindyalov Ilya |
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Institution: | Ceres Inc, 3007 Malibu Canyon Road, Malibu, CA 90265, USA. nicka@ceres-inc.com |
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Abstract: | We have developed a program for automatic identification of domains in protein three-dimensional structures. Performance of the program was assessed by three different benchmarks: (i) by comparison with the expert-curated SCOP database of structural domains; (ii) by comparison with a collection of manual domain assignments; and (iii) by comparison with a set of 55 proteins, frequently used as a benchmark for automatic domain assignment. In all these benchmarks PDP identified domains correctly in more than 80% of proteins. AVAILABILITY: http://123d.ncifcrf.gov/. |
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