Synthesis of new N-sulfonylated amino alcohols and application to the enantioselective addition of diethylzinc to aldehydes |
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| Authors: | Hui Xin-Ping Chen Chien-An Gau Han-Mou |
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| Affiliation: | Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan. |
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| Abstract: | A series of N-sulfonylated amino alcohols were prepared and the enantioselective addition of diethylzinc to aldehydes catalyzed by titanium(IV) complexes of those ligands were carried out. Excellent enantioselectivities were obtained for the desired alcohols with enantiomeric excess values up to 94% of R-configuration. |
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| Keywords: | asymmetric addition amino alcohol (+)‐10‐camphorsulfonyl chloride diethylzinc titanium tetraisopropoxide |
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