| 长链非编码RNA、焦亡和心肌缺血-再灌注损伤 |
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| 引用本文： | 何东,胡佳,陈娟,韦星. 长链非编码RNA、焦亡和心肌缺血-再灌注损伤[J]. 生物化学与生物物理进展, 2019, 46(12): 1171-1178 |
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| 作者姓名： | 何东 胡佳 陈娟 韦星 |
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| 作者单位： | 南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，湖南省动脉硬化性疾病国际科技创新合作基地,衡阳 421001,南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，湖南省动脉硬化性疾病国际科技创新合作基地,衡阳 421001,南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，湖南省动脉硬化性疾病国际科技创新合作基地,衡阳 421001,南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，湖南省动脉硬化性疾病国际科技创新合作基地,衡阳 421001 |
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| 摘 要： | 急性心肌梗死后的再灌注是挽救缺血心肌的唯一方法，但是血流的恢复可能导致心肌缺血-再灌注损伤. 长链非编码RNA(lncRNA)和焦亡都参与了心肌缺血-再灌注损伤的病理过程并发挥重要作用. lncRNA能直接或者间接作用于焦亡信号通路相关蛋白质，对包括心肌缺血-再灌注损伤在内的多种病理过程进行调控. 本文就lncRNA和焦亡在心肌缺血-再灌注损伤中的作用做一综述，以进一步探索两者关系，为防治心肌缺血-再灌注损伤提供新思路.
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| 关 键 词： | 长链非编码RNA 焦亡 心肌缺血-再灌注损伤 |
| 收稿时间： | 2019-07-23 |
| 修稿时间： | 2019-11-10 |
Long Non-coding RNA,Pyroptosis and Myocardial Ischemia/Reperfusion Injury |
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| HE Dong,HU Ji,CHEN Juan and WEI Xing. Long Non-coding RNA,Pyroptosis and Myocardial Ischemia/Reperfusion Injury[J]. Progress In Biochemistry and Biophysics, 2019, 46(12): 1171-1178 |
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| Authors: | HE Dong HU Ji CHEN Juan WEI Xing |
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| Affiliation: | Institute of Cardiovascular Diseases, University of South China & Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang 421001, China,Institute of Cardiovascular Diseases, University of South China & Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang 421001, China,Institute of Cardiovascular Diseases, University of South China & Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang 421001, China,Institute of Cardiovascular Diseases, University of South China & Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang 421001, China |
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| Abstract: | Reperfusion after acute myocardial infarction is the only way to rescue ischemic myocardium, but recovery of blood flow may lead to ischemia/reperfusion (I/R) injury. Long non-coding RNA (lncRNA) and pyroptosis are involved in the pathological process of myocardial I/R injury and play important roles in it. LncRNA can directly or indirectly act on pyroptosis signaling pathway related proteins, and then regulate various pathological processes including myocardial I/R injury. In this review the roles of lncRNA and pyroptosis in myocardial I/R are summarized to further explore the relationship between them and provide new ideas for the prevention and treatment of myocardial I/R injury. |
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| Keywords: | long non-coding RNA pyroptosis myocardial ischemia/reperfusion injury |
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