Signal sequence cleavage of peptidyl-tRNA prior to release from the ribosome and translocon |
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Authors: | Wollenberg Michael S Simon Sanford M |
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Affiliation: | Laboratory of Cellular Biophysics, Rockefeller University, New York, New York 10021, USA. |
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Abstract: | Many secretory polypeptides undergo cleavage of their signal sequence. In this study, we observed and quantitated the presence of a tRNA-bound, ribosome-associated polypeptide subpopulation present in vitro. This subpopulation was accessible to signal peptidase on ribosome-associated polypeptides longer than 114 amino acids. This demonstrates that it is possible for a peptidyl-tRNA species, in the midst of translation, to be processed by the endoplasmic reticulum signal peptidase implying that the peptidase is closely associated with the mammalian translocon. |
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