orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins |
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Authors: | Pablo Mier Miguel A Andrade-Navarro Antonio J Pérez-Pulido |
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Institution: | 1. Centro Andaluz de Biología del Desarrollo (CABD), CSIC-UPO-JA. Facultad de Ciencias Experimentales (Área de Genética), Universidad Pablo de Olavide, ES-41013, Sevilla, Spain.; 2. Faculty of Biology, Johannes Gutenberg University Mainz, Mainz, Germany.; 3. Institute of Molecular Biology, Mainz, Germany.; Aberystwyth University, UNITED KINGDOM, |
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Abstract: | Finding homologous and orthologous protein sequences is often the first step in evolutionary studies, annotation projects, and experiments of functional complementation. Despite all currently available computational tools, there is a requirement for easy-to-use tools that provide functional information. Here, a new web application called orthoFind is presented, which allows a quick search for homologous and orthologous proteins given one or more query sequences, allowing a recurrent and exhaustive search against reference proteomes, and being able to include user databases. It addresses the protein multidomain problem, searching for homologs with the same domain architecture, and gives a simple functional analysis of the results to help in the annotation process. orthoFind is easy to use and has been proven to provide accurate results with different datasets. Availability: http://www.bioinfocabd.upo.es/orthofind/. |
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