A point mutation in the VP4 coding sequence of coxsackievirus B4 influences virulence. |
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Authors: | A I Ramsingh and D N Collins |
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Abstract: | In analyzing the molecular determinants of virulence of coxsackievirus B4, chimeric viruses were constructed from avirulent and virulent viruses. The vCB424 recombinant contained a single nucleotide substitution on an avirulent genetic background, resulting in replacement of Ser-16 of VP4 with Arg-16. Mice infected with vCB424 displayed an intermediate phenotype. |
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