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Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains |
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| Authors: | Hiwa M?len Gustavo A De Souza Sharad Pathak Tina S?fteland and Harald G Wiker |
| Institution: | (1) Section for Microbiology and Immunology, the Gade Institute, University of Bergen, Bergen, Norway;(2) Department of Microbiology and Immunology, Haukeland University Hospital, Bergen, Norway;(3) Proteomic Unit, Department of Biomedicine, University of Bergen, Bergen, Norway |
| Abstract: | BackgroundThe potential causes for variation in virulence between distinct M. tuberculosis strains are still not fully known. However, differences in protein expression are probably an important factor. In this study we used a label-free quantitative proteomic approach to estimate differences in protein abundance between two closely related M. tuberculosis strains; the virulent H37Rv strain and its attenuated counterpart H37Ra. |
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