Identification of (Na,K)ATPase inhibitor in brine shrimp,Artemia salina,as long-chain fatty acids |
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| Authors: | Michiaki Morohashi Keiko Tsuchiya Takashi Mita Masaru Kawamura |
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| Affiliation: | (1) Department of Biology and Molecular Biology, University of Occupational and Environmental Health, Yahatanishi, 807 Kitakyushu, Japan;(2) Department of Biology, Faculty of Science, Chiba University, Yayoi, 260 Chiba, Japan |
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| Abstract: | Summary An inhibitory activity to (Na,K)ATPase was found in cell extracts of the brine shrimp, Artemia salina, irrespective of its developmental stages. Organic solvent extraction together with gas chromatographic analysis reveals that the inhibitory activity is due to long-chain, non-esterified fatty acids and their derivatives. Unsaturated fatty acids, especially with cis-configuration, are more effective in inhibition than saturated ones.Abbreviations ATPase adenosine triphosphatase - EDTA ethylenediamine-tetraacetate - TLC thin-layer chromatography |
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| Keywords: | (Na,K)ATPase inhibitor Fatty acid Artemia salina |
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