Contrasting effects of Org 2766 and alpha-MSH on social and exploratory behavior in the rat |
| |
Authors: | S E File |
| |
Institution: | Department of Pharmacology, The School of Pharmacy, University of London Brunswick Square, London WC1N 1AX, England |
| |
Abstract: | Intraperitoneal injection of Org 2766 (0.01-0.4 microgram/kg) produced a dose-related increase in the number of social contacts and in the time spent in active social interaction by pairs of male rats tested in arenas with which they were familiar, but had little effect when the rats were tested in unfamiliar arenas. The increased social interaction was not accompanied by any change in motor activity. In contrast, alpha-MSH (20-200 microgram/kg) decreased the time spent in active social dose-related. Both peptides reduced exploratory head-dipping only at high doses (4-8 microgram/kg for Org 2766 and 200 microgram/kg for alpha-MSH); this change was not accompanied by a reduction in motor activity. |
| |
Keywords: | ACTH Org 2766 Social behavior Exploration Motor activity Defecation |
本文献已被 ScienceDirect 等数据库收录! |