Glycolipids and myelin proteins in human oligodendrogliomas |
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Authors: | C. -C. Sung R. Collins J. Li D. K. Pearl Stephen W. Coons Bernd W. Scheithauer Peter C. Johnson A. J. Yates |
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Affiliation: | (1) Division of Neuropathology, The Ohio State University, 43210 Columbus, OH, USA;(2) Department of Statistics, The Ohio State University, 43210 Columbus, OH, USA;(3) Department of Neuropathology, Barrow Neurological Institute, 85013 Phoenix, AZ, USA;(4) Department of Pathology, Mayo Clinic, 55905 Rochester, MN, USA |
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Abstract: | We studied myelin proteins and glycolipids in 24 human oligodendrogliomas (16 pure, eight mixed), including two grade I, 13 grade II, five grade III, and four grade IV Tumours with a 1b ganglioside content (GD1b, GT1b and GQ1b) over 30% of total gangliosides occur more frequently in the WHO grade I II and (47%) and grade III (40%) than in the grade IV (25%) group; there was no difference in the amounts of total ganglioside or individual gangliosides between pure and mixed oligodendrogliomas. The presence of 6-LM1 correlated with higher grades of tumours (2p0.02); however, 3-LM1 and total neolacto-series gangliosides did not correlate with grade. Immunohistochemical studies of oligodendrocyte and myelin markers (GalCer, sulfatide, 2,3-cyclic nucleotide phosphodiesterase, myelin basic protein and proteolipid protein) using specific antibodies showed only a very small proportion of tumour cells staining. These data do not support the hypothesis that tumours classified as oligodendrogliomas are derived from mature oligodendrocytes. |
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Keywords: | brain tumours glioma gangliosides glycolipids myelin proteins |
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