VERÄNDERUNGEN DER AMINOSÄUREKONZENTRATIONEN IM RATTENHIRN BEI VERRINGERUNG DER K+-ZUFUHR IN VIVO

Abstract—

• 1 Resonium A, a cation exchange resin, administered orally caused no decrease of the potassium content in the CNS of the rat, but it provoked a potassium depletion in the liver tissue. However a slight increase could be detected in the ‘cortex’ and ‘striatum’.
• 2 A rise of the concentration of the free amino acids was found in ‘cortex’, ‘striatum’, ‘thalamus’ and cerebellum. Glutamic acid showed an increase of 70–80 per cent. GABA and glycine showed a remarkable increase of 280–330 per cent.
• 3 Restitution of K⁺ by feeding a potassium-rich diet brought the amino acid concentrations in the ‘cortex’ and cerebellum within a normal range. In ‘striatum’ and ‘thalamus’ an overshoot could be observed.
• 4 The experimental procedure for the estimation of free amino acids in brain tissue is discussed.