From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization |
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| Authors: | Mark K Schlegel,Maja M Janas,Yongfeng Jiang,Joseph D Barry,Wendell Davis,Saket Agarwal,Daniel Berman,Christopher R Brown,Adam Castoreno,Sarah LeBlanc,Abigail Liebow,Tara Mayo,Stuart Milstein,Tuyen Nguyen,Svetlana Shulga-Morskaya,Sarah Hyde,Sally Schofield,John Szeto,Lauren Blair Woods,Vedat O Yilmaz,Muthiah Manoharan,Martin Egli,Klaus Charissé ,Laura Sepp-Lorenzino,Patrick Haslett,Kevin Fitzgerald,Vasant Jadhav,Martin A Maier |
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| Affiliation: | Alnylam Pharmaceuticals, Inc., Cambridge, MA 02142, USA;Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA |
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