Regulation of the lysosome by sphingolipids: Potential role in aging |
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Authors: | Haiqing Tang Xiaokun Huang Shanshan Pang |
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Affiliation: | School of Life Sciences, Chongqing University, Chongqing, China |
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Abstract: | Sphingolipids are a class of bioactive complex lipids that have been closely associated with aging and aging-related diseases. However, the mechanism through which sphingolipids control aging has long been a mystery. Emerging studies reveal that sphingolipids exert tight control over lysosomal homeostasis and function, as evidenced by sphingolipid-related diseases, including but not limited to lysosomal storage disorders. These diseases are defined by primary lysosomal defects and a few secondary defects such as mitochondrial dysfunction. Intriguingly, recent research indicates that the majority of these defects are also associated with aging, implying that sphingolipid-related diseases and aging may share common mechanisms. We propose that the lysosome is a pivotal hub for sphingolipid-mediated aging regulation. This review discusses the critical roles of sphingolipid metabolism in regulating various lysosomal functions, with an emphasis on how such regulation may contribute to aging and aging-related diseases. |
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Keywords: | sphingolipid, lysosome, aging, life span, mTOR, lysosomal calcium, lysosomal cell death, lysosome– mitochondria communication |
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