Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2 |
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| Authors: | Han C K Ahn S K Choi N S Hong R K Moon S K Chun H S Lee S J Kim J W Hong C I Kim D Yoon J H No K T |
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| Institution: | Chong Kun Dang Research Institute, Chungcheongnamdo, South Korea. |
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| Abstract: | New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470. |
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